Morphofunctional characteristics of working cardiomyocytes in offspring of mothers with experimental type 1 diabetes in the early neonatal period

The aim of this research was to analyze the features morphofunctional state left ventricular contractile cardiomyocytes offspring mothers with experimental type 1 diabetes mellitus during neonatal period. Diabetes modeled in sexually mature female rats using streptozotocin. Specific area myocardial stroma and parenchyma, number cardiomyocytes, nuclear-cytoplasmic ratio, content binucleated cells, as well glycogen were determined on serial histological sections. It has been established that there is a decrease cardiac muscle tissue, an increase cytoplasmic excessive accumulation them. At same time, bicore significantly decreases comparison control group. results obtained allow us conclude maternal negative effect formation apparatus heart.